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A cikin marasa lafiya tare da ƙananan ƙwayoyin cuta na cardiomyopathy (MDCM), haɓakar ƙididdiga na furotin C-reactive sosai (hs-CRP) suna da alaƙa da ƙara yawan matakan N-terminal brain natriuretic peptide (NT-proBNP) a cikin marasa lafiya tare da m dilated cardiomyopathy (MDCM) .), ko da yake babu wata shaida don tallafawa tasirin tsinkaya da ke hade da sakamakon haƙuri.An buga sakamakon a cikin mujallar ESC Heart Failure.
An yi nazari na baya-bayan nan game da marasa lafiya da ke fama da cututtukan zuciya (DCM) da ɓangarorin fitar da ventricular ejection kasa da kashi 50% da aka shigar a Asibitin Fuwai da ke birnin Beijing, China daga Disamba 2006 zuwa Oktoba 2017.Masu binciken sun nemi kwatanta masu biomarkers NT-proBNP da hs-CRP a cikin marasa lafiya na MDCM da marasa lafiya na DCM.A cikin wannan binciken, an bayyana MDCM azaman maƙasudin diastolic diastolic end-ventricle na hagu (LVEDDi) na 33 mm/m2 ko ƙasa da haka a cikin maza da 34 mm/m2 a cikin mata.
An haɗa jimlar mahalarta 640 a cikin bincike, wanda 17% an rarraba su azaman suna da MDCM kuma 83% an rarraba su azaman suna da DCM a asali.Gabaɗaya, kashi 24.8% na mahalarta taron mata ne.Matsakaicin shekarun marasa lafiya shine shekaru 49.
Idan aka kwatanta da mahalarta DCM, marasa lafiya na MDCM sun kasance ƙanana, suna da hawan jini mafi girma, yawan kamuwa da ciwon sukari, ƙananan adadin tachycardia maras kyau, mafi girman ma'auni na jiki, da ɗan gajeren zaman asibiti. Game da cututtukan zuciya na zuciya, marasa lafiya tare da MDCM suna da ƙananan matakan NT-proBNP masu mahimmanci idan aka kwatanta da marasa lafiya tare da DCM (2203 pg/mL vs 1448 pg/mL, bi da bi; P <.001). Game da masu amfani da kwayoyin halitta, marasa lafiya tare da MDCM suna da ƙananan matakan NT-proBNP masu mahimmanci idan aka kwatanta da marasa lafiya tare da cardiac DCM (2203 pg / mL vs 1448 pg / mL, bi da bi; P <.001). Что касается сердечных биомаркеров, у пациентов с MDCM средний уровень NT-proBNP был значительно ниже по сравнению с пациентами с DCM (2203 пг/мл против 1448 пг/мл соответственно; P < 0,001). Dangane da alamun cututtukan zuciya na zuciya, marasa lafiya na MDCM suna da ƙananan ma'anar NT-proBNP matakan da aka kwatanta da marasa lafiya na DCM (2203 pg/mL vs. 1448 pg/mL, bi da bi; P <0.001).关于心脏生物标志物,与DCM 患者相比,MDCM 患者的NT-proBNPMDCM 患者的NT-proBNP 水平中位数显着降低(分别,与2203 pg/mL 和L0.0 pg/mL 和L0.0 Что касается сердечных биомаркеров, у пациентов с MDCM средний уровень NT-proBNP был значительно ниже по сравнению с пациентами с DCM (2203 пг/мл и 1448 пг/мл соответственно; P < 0,001). Dangane da alamun cututtukan zuciya, ma'anar matakan NT-proBNP sun ragu sosai a cikin marasa lafiya na MDCM idan aka kwatanta da marasa lafiya na DCM (2203 pg/mL da 1448 pg/mL, bi da bi; P <0.001).Ya bambanta, ma'anar hs-CRP matakan sun kasance mafi girma a cikin marasa lafiya na MDCM fiye da marasa lafiya na DCM (3.09 mg / L da 2.79 mg / L, bi da bi; P = 0.39).
Daga cikin marasa lafiya na 282 da suka yi bibiyar echocardiographic a cikin tsaka-tsakin watanni 6 ko fiye, 7 marasa lafiya tare da MDCM (11.1%) sun haɓaka DCM, yayin da marasa lafiya 70 tare da DCM (32.0%) suka koma MDCM, kamar yadda aka samu canji a LVEDDi.
Baseline MDCM marasa lafiya suna da ƙananan haɗarin haɗin gwiwa na duk-mutuwar mace-mace, dasawa da zuciya, da kuma sake dawowa don raunin zuciya idan aka kwatanta da mahalarta DCM (daidaitaccen haɗarin haɗari [aHR], 0.63; 95% CI, 0.43-0.93; P = 0.019).
Duk matakan hs-CRP da NT-proBNP an haɗa su da kansu tare da haɗin gwiwar ƙarshen duka a cikin ƙungiyar binciken (hs-CRP, aHR, 1.07; 95% CI, 1.00-1.15 da NT-proBNP: aHR, 1.11, 95% CI, 1.02-1.22, p = 0.019).
Bayan kwatanta ƙididdige ƙididdiga tsakanin MDCM da DCM, ƙungiyar tsakanin manyan matakan NT-proBNP da haɗin gwiwa sun kasance daidai da wanda aka ruwaito kafin kwatanta marasa lafiya tare da DCM (RR, 1.83; 95% CI, 1.05-3.20; P = 0.034), amma ba a cikin marasa lafiya tare da MDCM (HR, 1.54, 95% CI, 0.76-3.11, P = 0.227).Ya bambanta, matakan hs-CRP har yanzu suna da alaƙa da tsinkaye a cikin marasa lafiya tare da MDCM (RR 3.19; 95% CI 1.52-6.66; P = 0.002), amma ba a cikin marasa lafiya tare da DCM (RR 1.04; 95% CI).0.61–1.79;p = 0.88).
Ƙayyadaddun binciken shine cewa nau'in nau'in marasa lafiya na iya canzawa yayin biyowa, ko da yake yawan mutanen da suka yi maimaita echocardiography sun kasance kadan, don haka ba a bincikar masu tsinkaye na phenotypic canji ba.Bugu da ƙari, saboda ƙananan samfurin marasa lafiya na MDCM a cikin binciken, abubuwan da za su iya rikicewa ba su da cikakkiyar daidaitawa a cikin bincike mai yawa.
"Hs-CRP na asali yana hade da sakamakon hadewa a cikin marasa lafiya na MDCM kafin da kuma bayan daidaitawa ga masu haɗin gwiwa, yayin da NT-proBNP kawai ke hade da sakamako a cikin DCM," in ji marubutan binciken."Ana buƙatar ƙarin karatu don bincika masu hasashen canje-canje a cikin lissafi na ventricular da aikin zuciya, musamman a cikin marasa lafiya tare da MDCM, don samar da ingantacciyar haɗarin haɗari."
Bayyanawa: Babu ɗaya daga cikin marubutan binciken da ya yi ikirarin alaƙa da fasahar kere-kere, magunguna, da/ko kamfanonin na'ura.
Feng J, Tian P, Liang L, et al.Sakamakon da ƙimar tsinkaya na N-terminal pro-brain peptide natriuretic peptide da haɓakar haɓakar furotin C-reactive a cikin ƙananan ƙwayoyin cuta na cardiomyopathies.ESC gazawar zuciya.An buga akan layi Maris 4, 2022 doi: 10.1002/ehf2.13864
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Lokacin aikawa: Satumba-23-2022